Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region
Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region
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BACKGROUND: Vitamin D binding protein is a main vitamin D copyright in serum.It also has an impact on macrophagial function.Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard.AIMS: To evaluate the vitamin D binding protein polymorphism in patients with acute coronary syndrome without diabetes mellitus, autoimmune diseases and malignant tumors.
Determine correlation, if there is, between vitamin D binding protein allele and features of acute coronary syndrome among this patient group.MATERIALS AND METHODS: It is a cross-sectional observational study.Study subjects Carabinas are patients with acute coronary syndrome.Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors.
In all participants were evaluated: predisposing factors for heart diseases, CBC, biochemical blood test, troponin, coronarography, echocardiography.The study lasted for 5 months from November 2017 until March 2018.Primary end point – assessment of vitamin D binding protein polymorphysm in this group of patients with acute coronary syndrome by means of vitamin D binding protein gene sequencing.50 patients were enrolled into this study who were urgently admitted to hospital and diagnosed with acute coronary syndrome.
Among them – 36 males and 14 females.Mean age was 60 (55;66) years.All participants were sequenced for single nucleotide polymorphysm in VDBP p.T436K (rs4588) and P.
432E (rs7041).RESULTS: Gene polymorphysms of interest were found in 43 patients among 50 enrolled.Haplotype Gc1s/2 (rs7041G-rs4588A) was found in 7 (14%) patients, Gc2 (rs7041T-rs4588A) — in 9 (18%) patients, Gc1s (rs7041G-rs4588C) – in 20 (40%) patients, Gc1f (rs7041T-rs4588C) in 14 (28%).Coronarography showed that coronary artery occlusions obstructing more than 50% of vessel lumen was found in 16 patients; obstruction greater than 90% was seen in 8 patients; total occlusion – in 4 patients.
CONCLUSIONS: In patient group with acute coronary syndrome prevalence of vitamin D binding protein gene polymorphysm was high – in 86% of participants.The features of Gc2 haplotype were higher frequency of recurrent myocardial infarction and total coronary artery occlusion, as well as tendency to decreased serum vitamin Quilting Books D3 (25(OH)D) levels.